![]() ![]() (PtBA-g-PS)-co-PPEGMEA formed large compound micelles in aqueous media, whereas (PAA-g-PS)-co-PPEGMA (polyacrylic acid)-g-polystyren)-co-poly(ethylene glycol) methacrylate self-assembled into bowl-shaped micelles with a hole at the edge of the micelles. synthesized asymmetric brush polymers (PtBA-g-PS)-co-PPEGMEA polytert-butyl2-((2-bromopropanoyloxy)-methyl)acrylate-g-polystyrene)-co-poly (ethylene glycol) methyl ether methacrylate via the RAFT polymerization of polyethylenglycole (PEG) methacrylate with tert-butyl 2-((2-bromopropanoyloxy)methyl) acrylate and ATRP of styrene. It was shown that PEG-b-(PAA-g-PLA) poly(ethylene glycol)-b-(polyacrylic acid)-g-poly(lactic acid), amphiphilic brush polymers synthesized via RAFT polymerization aggregated into spheres and vesicles with sizes of 70–110 nm in aqueous media. The copolymer chains associate during the first thermal transition and then undergo a rearrangement process at the second thermal transition to produce a stable core–shell micellar structure. ![]() In comparison to other thermoresponsive random copolymers based on oligo(ethylene glycol) methacrylates, this copolymer exhibited an unusual thermally induced two-stage aggregation process. mol –1) was synthesized using the atom transfer radical polymerization (ATRP) process, and its thermoresponsive behavior in water solution were studied.mol –1) and poly(ethylene glycol) methyl ether methacrylate (PEGMA, M = 2080 g.mol –1) containing 2-(2-methoxyethoxy)ethylmethacrylate (MEO 2MA, M = 188 g.The copolymer poly(MEO 2MA-co-PEGMA2080 ( M n = 17,300 g P(OEGMA188- co-AAm) with a high mole fraction of AAm demonstrates “schizophrenic” behavior in wettability after immersion in pH buffer solutions, with transitions that mimic LCST and UCST for pH = 3, LCST for pH = 5 and 7, and temperature-induced transitions blocked for pH = 9.įor the synthesis of MOEGM copolymers with a given architecture such as block copolymers, brushes, star polymers, and dendrimers, as well as low-molar-mass distribution, the method of reversible addition–fragmentation chain transfer (RAFT) radical polymerization is used. In, a series of novel temperature-responsive copolymer brushes with P-(2-(2-methoxyethoxy)ethyl methacrylate)- co-acrylamide) (P-(OEGMA188- co-AAm)) chains grafted from glass surfaces functionalized with (3-aminopropyl)triethoxysilane followed by the ATRP initiator were synthesized. Amphiphilic (co)polymers methoxiolygoethylenglycolmethacrylate (MOEGM) have good biocompatibility and low toxicity, are susceptible to biodegradation, and have low critical solution temperature, which is close to human body temperature. The most rapidly developing method of obtaining polymer particles with a surface from polyethylene glycol fragments is the use of macromonomers, namely the derivatives of (meth)acrylic acid with ethylene glycol groups in the substituent. It allows the particle to circulate through the circulatory system for a long time and penetrate through various membranes and the blood–brain barrier. One of them is polyethylene glycol (PEG). One convenient way to create a shell for polymer nanoparticles is using thermo- and pH-responsive polymers. ![]() It was shown that at a given molecular mass and at close pH values, the increase in the number of N-methacrylamide units led to an increase in phase separation temperatures. Molecular brushes demonstrated thermo- and pH-responsiveness in water–salt solutions. Critical micelle concentrations decreased with the content of N-methacrylamide. In water, micelle-like aggregates were formed. The macromolecules of these polymer brushes were modeled using a prolate revolution ellipsoid or a cylinder with spherical ends. The molar masses of the prepared samples ranged from 40,000 to 60,000 g The solvents used were acetonitrile, DMFA, and water. ![]() Molar masses and hydrodynamic characteristics were obtained using static and dynamic light scattering and viscometry. The “grafting-through” approach was used to prepare the low-molar-mass dispersion samples ( M w/ M n ≈ 1.3). The thermo- and pH-responsive polymer brushes based on methoxymethacrylate with different concentrations of N-methacrylamide (from 0% to 20%) were synthesized via RAFT polymerization. ![]()
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